Differential neurodegenerative phenotypes are associated with heterogeneous voiding dysfunction in a coronavirus-induced model of multiple sclerosis
Identifieur interne : 000662 ( Main/Exploration ); précédent : 000661; suivant : 000663Differential neurodegenerative phenotypes are associated with heterogeneous voiding dysfunction in a coronavirus-induced model of multiple sclerosis
Auteurs : Sanghee Lee [États-Unis] ; Balachandar Nedumaran ; Joseph Hypolite ; Brian Caldwell ; Michael C. Rudolph ; Anna P. MalykhinaSource :
- Scientific Reports [ 2045-2322 ] ; 2019.
Abstract
Patients with multiple sclerosis (MS) develop a variety of lower urinary tract symptoms (LUTS). We previously characterized a murine model of neurogenic bladder dysfunction induced by a neurotropic strain of a coronavirus. In the present study, we further study the role of long-lasting neurodegeneration on the development of neurogenic bladder dysfunction in mice with corona-virus induced encephalitis (CIE). Long-term follow up study revealed three phenotypes of neurodegenerative symptom development: recovery (REC group), chronic progression (C-PRO group) and chronic disease with relapsing-remitting episodes (C-RELAP group). The levels of IL-1β in REC group, IL-10 in C-RELAP group, and IL-1β, IL-6, IL-10 and TNF-α in C-PRO group were diminished in the brain. The levels of TNF-α in REC group and INF-γ, IL-2, TGF-β and TNF-α in the C-PRO group were also diminished in the urinary bladder. Mice in C-RELAP group showed a delayed recovery of voiding function.
Url:
DOI: 10.1038/s41598-019-47407-x
PubMed: 31350464
PubMed Central: 6659655
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000158
- to stream Pmc, to step Curation: 000158
- to stream Pmc, to step Checkpoint: 000085
- to stream PubMed, to step Corpus: 000592
- to stream PubMed, to step Curation: 000592
- to stream PubMed, to step Checkpoint: 000596
- to stream Ncbi, to step Merge: 000784
- to stream Ncbi, to step Curation: 000784
- to stream Ncbi, to step Checkpoint: 000784
- to stream Main, to step Merge: 000664
- to stream Main, to step Curation: 000662
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential neurodegenerative phenotypes are associated with heterogeneous voiding dysfunction in a coronavirus-induced model of multiple sclerosis</title><author><name sortKey="Lee, Sanghee" sort="Lee, Sanghee" uniqKey="Lee S" first="Sanghee" last="Lee">Sanghee Lee</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 4242</institution-id><institution-id institution-id-type="GRID">grid.266100.3</institution-id><institution>Department of Urology,</institution><institution>University of California San Diego,</institution></institution-wrap>La Jolla, California USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>La Jolla</wicri:cityArea></affiliation></author><author><name sortKey="Nedumaran, Balachandar" sort="Nedumaran, Balachandar" uniqKey="Nedumaran B" first="Balachandar" last="Nedumaran">Balachandar Nedumaran</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0703 675X</institution-id><institution-id institution-id-type="GRID">grid.430503.1</institution-id><institution>Division of Urology, Department of Surgery,</institution><institution>University of Colorado Denver,</institution></institution-wrap>Aurora, Co USA</nlm:aff><wicri:noCountry code="subfield">Co USA</wicri:noCountry></affiliation></author><author><name sortKey="Hypolite, Joseph" sort="Hypolite, Joseph" uniqKey="Hypolite J" first="Joseph" last="Hypolite">Joseph Hypolite</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0703 675X</institution-id><institution-id institution-id-type="GRID">grid.430503.1</institution-id><institution>Division of Urology, Department of Surgery,</institution><institution>University of Colorado Denver,</institution></institution-wrap>Aurora, Co USA</nlm:aff><wicri:noCountry code="subfield">Co USA</wicri:noCountry></affiliation></author><author><name sortKey="Caldwell, Brian" sort="Caldwell, Brian" uniqKey="Caldwell B" first="Brian" last="Caldwell">Brian Caldwell</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0703 675X</institution-id><institution-id institution-id-type="GRID">grid.430503.1</institution-id><institution>Division of Urology, Department of Surgery,</institution><institution>University of Colorado Denver,</institution></institution-wrap>Aurora, Co USA</nlm:aff><wicri:noCountry code="subfield">Co USA</wicri:noCountry></affiliation></author><author><name sortKey="Rudolph, Michael C" sort="Rudolph, Michael C" uniqKey="Rudolph M" first="Michael C." last="Rudolph">Michael C. Rudolph</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0703 675X</institution-id><institution-id institution-id-type="GRID">grid.430503.1</institution-id><institution>Division of Endocrinology, Metabolism & Diabetes,</institution><institution>University of Colorado Denver,</institution></institution-wrap>Aurora, Co USA</nlm:aff><wicri:noCountry code="subfield">Co USA</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0703 675X</institution-id><institution-id institution-id-type="GRID">grid.430503.1</institution-id><institution>NORC Metabolic and Cellular Analysis Core Center for Women’s Health Research,</institution><institution>University of Colorado Denver,</institution></institution-wrap>Aurora, Co USA</nlm:aff><wicri:noCountry code="subfield">Co USA</wicri:noCountry></affiliation></author><author><name sortKey="Malykhina, Anna P" sort="Malykhina, Anna P" uniqKey="Malykhina A" first="Anna P." last="Malykhina">Anna P. Malykhina</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0703 675X</institution-id><institution-id institution-id-type="GRID">grid.430503.1</institution-id><institution>Division of Urology, Department of Surgery,</institution><institution>University of Colorado Denver,</institution></institution-wrap>Aurora, Co USA</nlm:aff><wicri:noCountry code="subfield">Co USA</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31350464</idno><idno type="pmc">6659655</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659655</idno><idno type="RBID">PMC:6659655</idno><idno type="doi">10.1038/s41598-019-47407-x</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000158</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000158</idno><idno type="wicri:Area/Pmc/Curation">000158</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000158</idno><idno type="wicri:Area/Pmc/Checkpoint">000085</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000085</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000592</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000592</idno><idno type="wicri:Area/PubMed/Curation">000592</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000592</idno><idno type="wicri:Area/PubMed/Checkpoint">000596</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000596</idno><idno type="wicri:Area/Ncbi/Merge">000784</idno><idno type="wicri:Area/Ncbi/Curation">000784</idno><idno type="wicri:Area/Ncbi/Checkpoint">000784</idno><idno type="wicri:Area/Main/Merge">000664</idno><idno type="wicri:Area/Main/Curation">000662</idno><idno type="wicri:Area/Main/Exploration">000662</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Differential neurodegenerative phenotypes are associated with heterogeneous voiding dysfunction in a coronavirus-induced model of multiple sclerosis</title><author><name sortKey="Lee, Sanghee" sort="Lee, Sanghee" uniqKey="Lee S" first="Sanghee" last="Lee">Sanghee Lee</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2107 4242</institution-id><institution-id institution-id-type="GRID">grid.266100.3</institution-id><institution>Department of Urology,</institution><institution>University of California San Diego,</institution></institution-wrap>La Jolla, California USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>La Jolla</wicri:cityArea></affiliation></author><author><name sortKey="Nedumaran, Balachandar" sort="Nedumaran, Balachandar" uniqKey="Nedumaran B" first="Balachandar" last="Nedumaran">Balachandar Nedumaran</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0703 675X</institution-id><institution-id institution-id-type="GRID">grid.430503.1</institution-id><institution>Division of Urology, Department of Surgery,</institution><institution>University of Colorado Denver,</institution></institution-wrap>Aurora, Co USA</nlm:aff><wicri:noCountry code="subfield">Co USA</wicri:noCountry></affiliation></author><author><name sortKey="Hypolite, Joseph" sort="Hypolite, Joseph" uniqKey="Hypolite J" first="Joseph" last="Hypolite">Joseph Hypolite</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0703 675X</institution-id><institution-id institution-id-type="GRID">grid.430503.1</institution-id><institution>Division of Urology, Department of Surgery,</institution><institution>University of Colorado Denver,</institution></institution-wrap>Aurora, Co USA</nlm:aff><wicri:noCountry code="subfield">Co USA</wicri:noCountry></affiliation></author><author><name sortKey="Caldwell, Brian" sort="Caldwell, Brian" uniqKey="Caldwell B" first="Brian" last="Caldwell">Brian Caldwell</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0703 675X</institution-id><institution-id institution-id-type="GRID">grid.430503.1</institution-id><institution>Division of Urology, Department of Surgery,</institution><institution>University of Colorado Denver,</institution></institution-wrap>Aurora, Co USA</nlm:aff><wicri:noCountry code="subfield">Co USA</wicri:noCountry></affiliation></author><author><name sortKey="Rudolph, Michael C" sort="Rudolph, Michael C" uniqKey="Rudolph M" first="Michael C." last="Rudolph">Michael C. Rudolph</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0703 675X</institution-id><institution-id institution-id-type="GRID">grid.430503.1</institution-id><institution>Division of Endocrinology, Metabolism & Diabetes,</institution><institution>University of Colorado Denver,</institution></institution-wrap>Aurora, Co USA</nlm:aff><wicri:noCountry code="subfield">Co USA</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0703 675X</institution-id><institution-id institution-id-type="GRID">grid.430503.1</institution-id><institution>NORC Metabolic and Cellular Analysis Core Center for Women’s Health Research,</institution><institution>University of Colorado Denver,</institution></institution-wrap>Aurora, Co USA</nlm:aff><wicri:noCountry code="subfield">Co USA</wicri:noCountry></affiliation></author><author><name sortKey="Malykhina, Anna P" sort="Malykhina, Anna P" uniqKey="Malykhina A" first="Anna P." last="Malykhina">Anna P. Malykhina</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0703 675X</institution-id><institution-id institution-id-type="GRID">grid.430503.1</institution-id><institution>Division of Urology, Department of Surgery,</institution><institution>University of Colorado Denver,</institution></institution-wrap>Aurora, Co USA</nlm:aff><wicri:noCountry code="subfield">Co USA</wicri:noCountry></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Patients with multiple sclerosis (MS) develop a variety of lower urinary tract symptoms (LUTS). We previously characterized a murine model of neurogenic bladder dysfunction induced by a neurotropic strain of a coronavirus. In the present study, we further study the role of long-lasting neurodegeneration on the development of neurogenic bladder dysfunction in mice with corona-virus induced encephalitis (CIE). Long-term follow up study revealed three phenotypes of neurodegenerative symptom development: recovery (REC group), chronic progression (C-PRO group) and chronic disease with relapsing-remitting episodes (C-RELAP group). The levels of IL-1β in REC group, IL-10 in C-RELAP group, and IL-1β, IL-6, IL-10 and TNF-α in C-PRO group were diminished in the brain. The levels of TNF-α in REC group and INF-γ, IL-2, TGF-β and TNF-α in the C-PRO group were also diminished in the urinary bladder. Mice in C-RELAP group showed a delayed recovery of voiding function. <italic>In vitro</italic> contractility studies determined a decreased basal detrusor tone and reduced amplitude of nerve-mediated contractions in C-RELAP group, whereas C-PRO group had elevated muscle-mediated contractions. In conclusion, mice with CIE developed three phenotypes of neurologic impairment mimicking different types of MS progression in humans and showed differential mechanisms driving neurogenic bladder dysfunction.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Campbell, Jd" uniqKey="Campbell J">JD Campbell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fowler, Cj" uniqKey="Fowler C">CJ Fowler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, H" uniqKey="Miller H">H Miller</name></author><author><name sortKey="Simpson, Ca" uniqKey="Simpson C">CA Simpson</name></author><author><name sortKey="Yeates, Wk" uniqKey="Yeates W">WK Yeates</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Betts, Cd" uniqKey="Betts C">CD Betts</name></author><author><name sortKey="D Ellow, Mt" uniqKey="D Ellow M">MT D’Mellow</name></author><author><name sortKey="Fowler, Cj" uniqKey="Fowler C">CJ Fowler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Borello France, D" uniqKey="Borello France D">D Borello-France</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hennessey, A" uniqKey="Hennessey A">A Hennessey</name></author><author><name sortKey="Robertson, Np" uniqKey="Robertson N">NP Robertson</name></author><author><name sortKey="Swingler, R" uniqKey="Swingler R">R Swingler</name></author><author><name sortKey="Compston, Da" uniqKey="Compston D">DA Compston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Awad, Sa" uniqKey="Awad S">SA Awad</name></author><author><name sortKey="Gajewski, Jb" uniqKey="Gajewski J">JB Gajewski</name></author><author><name sortKey="Sogbein, Sk" uniqKey="Sogbein S">SK Sogbein</name></author><author><name sortKey="Murray, Tj" uniqKey="Murray T">TJ Murray</name></author><author><name sortKey="Field, Ca" uniqKey="Field C">CA Field</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fernandez, O" uniqKey="Fernandez O">O Fernández</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mattson, D" uniqKey="Mattson D">D Mattson</name></author><author><name sortKey="Petrie, M" uniqKey="Petrie M">M Petrie</name></author><author><name sortKey="Srivastava, Dk" uniqKey="Srivastava D">DK Srivastava</name></author><author><name sortKey="Mcdermott, M" uniqKey="Mcdermott M">M McDermott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccombe, Pa" uniqKey="Mccombe P">PA McCombe</name></author><author><name sortKey="De Jersey, J" uniqKey="De Jersey J">J de Jersey</name></author><author><name sortKey="Pender, Mp" uniqKey="Pender M">MP Pender</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccombe, Pa" uniqKey="Mccombe P">PA McCombe</name></author><author><name sortKey="Fordyce, Bw" uniqKey="Fordyce B">BW Fordyce</name></author><author><name sortKey="De Jersey, J" uniqKey="De Jersey J">J de Jersey</name></author><author><name sortKey="Yoong, G" uniqKey="Yoong G">G Yoong</name></author><author><name sortKey="Pender, Mp" uniqKey="Pender M">MP Pender</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccombe, Pa" uniqKey="Mccombe P">PA McCombe</name></author><author><name sortKey="Nickson, I" uniqKey="Nickson I">I Nickson</name></author><author><name sortKey="Pender, Mp" uniqKey="Pender M">MP Pender</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rus, V" uniqKey="Rus V">V Rus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goverman, J" uniqKey="Goverman J">J Goverman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hemmer, B" uniqKey="Hemmer B">B Hemmer</name></author><author><name sortKey="Archelos, Jj" uniqKey="Archelos J">JJ Archelos</name></author><author><name sortKey="Hartung, Hp" uniqKey="Hartung H">HP Hartung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mizusawa, H" uniqKey="Mizusawa H">H Mizusawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vignes, Jr" uniqKey="Vignes J">JR Vignes</name></author><author><name sortKey="Deloire, Ms" uniqKey="Deloire M">MS Deloire</name></author><author><name sortKey="Petry, Kg" uniqKey="Petry K">KG Petry</name></author><author><name sortKey="Nagy, F" uniqKey="Nagy F">F Nagy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Correale, J" uniqKey="Correale J">J Correale</name></author><author><name sortKey="Li, S" uniqKey="Li S">S Li</name></author><author><name sortKey="Weiner, Lp" uniqKey="Weiner L">LP Weiner</name></author><author><name sortKey="Gilmore, W" uniqKey="Gilmore W">W Gilmore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Mt" uniqKey="Liu M">MT Liu</name></author><author><name sortKey="Keirstead, Hs" uniqKey="Keirstead H">HS Keirstead</name></author><author><name sortKey="Lane, Te" uniqKey="Lane T">TE Lane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Houtman, Jj" uniqKey="Houtman J">JJ Houtman</name></author><author><name sortKey="Fleming, Jo" uniqKey="Fleming J">JO Fleming</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcmillan, Mt" uniqKey="Mcmillan M">MT McMillan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Asfaw, Ts" uniqKey="Asfaw T">TS Asfaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="J Ger, A" uniqKey="J Ger A">A Jäger</name></author><author><name sortKey="Dardalhon, V" uniqKey="Dardalhon V">V Dardalhon</name></author><author><name sortKey="Sobel, Ra" uniqKey="Sobel R">RA Sobel</name></author><author><name sortKey="Bettelli, E" uniqKey="Bettelli E">E Bettelli</name></author><author><name sortKey="Kuchroo, Vk" uniqKey="Kuchroo V">VK Kuchroo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fletcher, Jm" uniqKey="Fletcher J">JM Fletcher</name></author><author><name sortKey="Lalor, Sj" uniqKey="Lalor S">SJ Lalor</name></author><author><name sortKey="Sweeney, Cm" uniqKey="Sweeney C">CM Sweeney</name></author><author><name sortKey="Tubridy, N" uniqKey="Tubridy N">N Tubridy</name></author><author><name sortKey="Mills, Kh" uniqKey="Mills K">KH Mills</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lamarre, Ns" uniqKey="Lamarre N">NS Lamarre</name></author><author><name sortKey="Braverman, As" uniqKey="Braverman A">AS Braverman</name></author><author><name sortKey="Malykhina, Ap" uniqKey="Malykhina A">AP Malykhina</name></author><author><name sortKey="Barbe, Mf" uniqKey="Barbe M">MF Barbe</name></author><author><name sortKey="Ruggieri, Mr" uniqKey="Ruggieri M">MR Ruggieri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ziemssen, T" uniqKey="Ziemssen T">T Ziemssen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lublin, Fd" uniqKey="Lublin F">FD Lublin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nylander, A" uniqKey="Nylander A">A Nylander</name></author><author><name sortKey="Hafler, Da" uniqKey="Hafler D">DA Hafler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, Cz" uniqKey="Lu C">CZ Lu</name></author><author><name sortKey="Fredrikson, S" uniqKey="Fredrikson S">S Fredrikson</name></author><author><name sortKey="Xiao, Bg" uniqKey="Xiao B">BG Xiao</name></author><author><name sortKey="Link, H" uniqKey="Link H">H Link</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Titelbaum, Ds" uniqKey="Titelbaum D">DS Titelbaum</name></author><author><name sortKey="Degenhardt, A" uniqKey="Degenhardt A">A Degenhardt</name></author><author><name sortKey="Kinkel, Rp" uniqKey="Kinkel R">RP Kinkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khavari, R" uniqKey="Khavari R">R Khavari</name></author><author><name sortKey="Elias, Sn" uniqKey="Elias S">SN Elias</name></author><author><name sortKey="Boone, T" uniqKey="Boone T">T Boone</name></author><author><name sortKey="Karmonik, C" uniqKey="Karmonik C">C Karmonik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phe, V" uniqKey="Phe V">V Phe</name></author><author><name sortKey="Chartier Kastler, E" uniqKey="Chartier Kastler E">E Chartier-Kastler</name></author><author><name sortKey="Panicker, Jn" uniqKey="Panicker J">JN Panicker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsunoyama, K" uniqKey="Tsunoyama K">K Tsunoyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tamam, Y" uniqKey="Tamam Y">Y Tamam</name></author><author><name sortKey="Ozdemir, Hh" uniqKey="Ozdemir H">HH Özdemir</name></author><author><name sortKey="Gedik, A" uniqKey="Gedik A">A Gedik</name></author><author><name sortKey="Tamam, C" uniqKey="Tamam C">C Tamam</name></author><author><name sortKey="Nazl Kul, H" uniqKey="Nazl Kul H">H Nazlıkul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruggieri, Michael R" uniqKey="Ruggieri M">Michael R. Ruggieri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tyagi, P" uniqKey="Tyagi P">P Tyagi</name></author><author><name sortKey="Tyagi, V" uniqKey="Tyagi V">V Tyagi</name></author><author><name sortKey="Yoshimura, N" uniqKey="Yoshimura N">N Yoshimura</name></author><author><name sortKey="Chancellor, M" uniqKey="Chancellor M">M Chancellor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giannantoni, A" uniqKey="Giannantoni A">A Giannantoni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beckel, Jm" uniqKey="Beckel J">JM Beckel</name></author><author><name sortKey="Birder, La" uniqKey="Birder L">LA Birder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tornic, J" uniqKey="Tornic J">J Tornic</name></author><author><name sortKey="Panicker, Jn" uniqKey="Panicker J">JN Panicker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burnstock, Geoffrey" uniqKey="Burnstock G">Geoffrey Burnstock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moss, He" uniqKey="Moss H">HE Moss</name></author><author><name sortKey="Tansey, Em" uniqKey="Tansey E">EM Tansey</name></author><author><name sortKey="Burnstock, G" uniqKey="Burnstock G">G Burnstock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altuntas, Cz" uniqKey="Altuntas C">CZ Altuntas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manaker, Ra" uniqKey="Manaker R">RA Manaker</name></author><author><name sortKey="Piczak, Cv" uniqKey="Piczak C">CV Piczak</name></author><author><name sortKey="Miller, Aa" uniqKey="Miller A">AA Miller</name></author><author><name sortKey="Stanton, Mf" uniqKey="Stanton M">MF Stanton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalincik, T" uniqKey="Kalincik T">T Kalincik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name></author><author><name sortKey="Yang, G" uniqKey="Yang G">G Yang</name></author><author><name sortKey="Bushman, W" uniqKey="Bushman W">W Bushman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lei, Q" uniqKey="Lei Q">Q Lei</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><noCountry><name sortKey="Caldwell, Brian" sort="Caldwell, Brian" uniqKey="Caldwell B" first="Brian" last="Caldwell">Brian Caldwell</name><name sortKey="Hypolite, Joseph" sort="Hypolite, Joseph" uniqKey="Hypolite J" first="Joseph" last="Hypolite">Joseph Hypolite</name><name sortKey="Malykhina, Anna P" sort="Malykhina, Anna P" uniqKey="Malykhina A" first="Anna P." last="Malykhina">Anna P. Malykhina</name><name sortKey="Nedumaran, Balachandar" sort="Nedumaran, Balachandar" uniqKey="Nedumaran B" first="Balachandar" last="Nedumaran">Balachandar Nedumaran</name><name sortKey="Rudolph, Michael C" sort="Rudolph, Michael C" uniqKey="Rudolph M" first="Michael C." last="Rudolph">Michael C. Rudolph</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Lee, Sanghee" sort="Lee, Sanghee" uniqKey="Lee S" first="Sanghee" last="Lee">Sanghee Lee</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000662 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000662 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6659655
|texte= Differential neurodegenerative phenotypes are associated with heterogeneous voiding dysfunction in a coronavirus-induced model of multiple sclerosis
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31350464" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidV1
| This area was generated with Dilib version V0.6.33. |  |